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Wanping Xu Selected Research

geldanamycin

7/2013Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors.
2/2005Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.
5/2004Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.
11/2003The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
5/2002Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy.

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Wanping Xu Research Topics

Disease

14Neoplasms (Cancer)
03/2021 - 05/2002
2Breast Neoplasms (Breast Cancer)
09/2008 - 11/2003
1Hepatocellular Carcinoma (Hepatoma)
03/2021
1Chronic Obstructive Pulmonary Disease (COPD)
01/2020
1Tuberculosis (Tuberculoses)
01/2020
1Lung Neoplasms (Lung Cancer)
01/2017
1Type 2 Diabetes Mellitus (MODY)
01/2014
1Neoplasm Metastasis (Metastasis)
07/2009
1Carcinogenesis
01/2007
1Ovarian Neoplasms (Ovarian Cancer)
10/2002

Drug/Important Bio-Agent (IBA)

7Heat-Shock Proteins (Heat-Shock Protein)IBA
03/2021 - 03/2003
5geldanamycinIBA
07/2013 - 05/2002
4Molecular Chaperones (Chaperone, Molecular)IBA
01/2014 - 03/2007
4Proteins (Proteins, Gene)FDA Link
01/2014 - 11/2003
2Phosphotransferases (Kinase)IBA
02/2014 - 05/2002
2Tyrosine Kinase InhibitorsIBA
07/2009 - 05/2002
2Gefitinib (Iressa)FDA Link
09/2008 - 11/2003
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2007 - 10/2002
1RNA Helicases (RNA Helicase)IBA
03/2021
1AcidsIBA
01/2020
1Biomarkers (Surrogate Marker)IBA
01/2017
1Endoplasmic Reticulum Chaperone BiPIBA
01/2016
1GlucocorticoidsIBA
02/2014
1Glucose (Dextrose)FDA LinkGeneric
01/2014
16- amino- 8- ((6- iodo- 1,3- benzodioxol- 5- yl)thio)- N- (1- methylethyl)- 9H-purine-9-propanamineIBA
07/2013
1Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
07/2009
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2008
1src-Family KinasesIBA
09/2008
1tanespimycin (17AAG)IBA
09/2008
1Insulin (Novolin)FDA Link
07/2006
1Insulin-Like PeptidesIBA
07/2006
1Anti-Bacterial Agents (Antibiotics)IBA
02/2005
1Bortezomib (Velcade)FDA Link
05/2004
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
11/2003
1Phosphoprotein Phosphatases (Phosphatases, Protein)IBA
11/2003
1Oncogene Proteins (Oncogene Protein)IBA
05/2002
1Tyrosine (L-Tyrosine)FDA Link
05/2002
1ErbB Receptors (EGF Receptor)IBA
05/2002
1NucleotidesIBA
05/2002
1Canertinib (CI 1033)IBA
05/2002

Therapy/Procedure

2Therapeutics
03/2003 - 05/2002